The primary functions of simple cuboidal epithelium include secretion, absorption, and protection. It forms a barrier that controls the exchange of substances between the underlying tissues and the external environment. For instance, in glands, this type of epithelium is responsible for producing and releasing hormones, enzymes, and other secretions. In kidney tubules, simple cuboidal epithelium plays a critical role in filtering blood and reabsorbing valuable substances, thereby contributing to the regulation of bodily fluids and electrolytes. Additionally, the structure of these cells, with their central nuclei, facilitates rapid metabolic activity and efficient transport across the cell membrane.